In a recent assessment of health literacy a significant proportion of students in education scored low (~40% misconceptions). These misconceptions and gaps in knowledge are then passed on from teachers to students later in their careers. This proposal establishes a collaborative, trans?disciplinary one health approach connecting scientific researchers, teachers and pupils. Although scientific research continuously uncovers the interconnections between our immune system, the microbiome, dietics and physical activity, a collaborative, trans?disciplinary one health approach is still needed. Medial information concerning topics of current and social relevance is often segregated and highly confusing for lay people. This proposal combines and transfers scientific and social knowledge to students, teachers and pupils. We propose (a) to investigate the intersections of findings by the different disciplines working with health issues, (b) to unravel common beliefs and misconceptions of pupils, students and biology teachers and (c) to address and communicate these issues at different levels of the education system. The project focuses on the role of teachers in mediating complex health?related topics as mediators of a sustainable and multiplying learning effect across generations. Project coordination is carried out by Mag. Dr. Irene Frischauf, MLBT who works at the JKU in Linz in the field of calcium signalling and its role in human health and disease. Benjamin Zwirzitz, MSc from the Veterinary University in Vienna contributes expertise in microbiome research and its influence onto the human immune system. Priv.?Doz. Dr. MMag. Clemens Drenowatz from the University of Education in Upper Austria (PH OÖ) is an expert in research focusing on the association between physical activity and health with focus on weight management. Priv.?Doz. Mag. Dr. Katharina Hirschenhauser is working in the division of Natural Science Education at the PH OÖ and is an expert in learning research.