Material System containing Endoperoxide with Adaption of Decomposition, and Applications
Sprache des Patenttitels:
This disclosure relates to the release of singlet oxygen by thermally activated decomposition of aromatic endoperoxide molecules in material systems [e.g. polymer (nano)particles or polymer films]. Due to the short lifespan and diffusion length of singlet oxygen, the technical problem is that the majority of the decomposition may only take place if the singlet oxygen molecules can reach the target region. For example, either the penetration of the polymer particles into the cancer cells to be killed, or the settlement of bacteria on an implant coated with the polymer film, must be accomplished. It is necessary to allow adaptation of the time progression of the decomposition for the application. The adaptation is performed by chemically and/or physically modifying the functional structures present in the material system, each made of the molecule forming the endoperoxide and at least one adjacent molecule or the cage formed by all adjacent molecules. Potential applications are in pharmacy and medicine, as well as in production technology.
Sprache der Kurzfassung:
US 9,969,617 B2
Jahr der Erteilung:
Appl. No.: 13/384,749, Filed: 21.07.2010, Date of patent: 15.05.2018