Water-?soluble metalated and non-?metalated A2B- and A3-?corrole?/amino acid conjugates: syntheses, characterization and properties
Sprache des Titels:
In this study, novel water-?sol. corrole amino acid conjugates were synthesized and characterized. The coupling reaction of A2B- and A3-?corroles with glycine Et ester and taurine under strong basic conditions proved to be successful and yielded di- and trifunctionalized corrole amino acid conjugates in good yields. The subsequent metalation of the corrole?/amino acid conjugates broadens the scope for applications considerably. As examples, we herein show the catalytic activity of the Mn(III) A3-?corrole towards O2 evolution. First we employed tert-?Bu hydroperoxide (t-?BuOOH) as oxidant to obtain the Mn(V)?oxo species and tetra-?Bu ammonium hydroxide (TBAH) as hydroxide donor agent. Furthermore, the binding properties of the non-?metalated and the Mn(III) A3-?corrole?/amino sulfonic acid conjugates and transport of proteins were investigated and the conjugates exhibited binding to human serum albumin (HSA)?. Finally, a novel Ga(III) A3-?corrole?/amino sulfonic acid deriv. was synthesized and we briefly describe the photophys. properties of this compd.