C. Turkay, A. Lex, Marc Streit, HP Pfister, H. Hauser,
"Characterizing Cancer Subtypes using the Dual Analysis Approach in Caleydo"
, in IEEE Computer Graphics and Applications, Vol. 34, Nummer 2, IEEE, Seite(n) 38-47, 3-2014, ISSN: 0272-1716
Original Titel:
Characterizing Cancer Subtypes using the Dual Analysis Approach in Caleydo
Sprache des Titels:
Englisch
Original Kurzfassung:
The comprehensive analysis and characterization of cancer subtypes is an important problem to which significant
resources have been devoted in recent years. In this paper we integrate the dual analysis method, which uses statistics to describe both the dimensions and the rows of a high dimensional dataset, into StratomeX, a Caleydo view tailored to cancer subtype analysis. We introduce significant difference plots for showing the elements of a candidate cancer subtype that differ significantly from other subtypes, thus enabling analysts to characterize cancer subtypes. We also enable analysts to investigate
how samples relate to the subtype they are assigned and to the other groups. Our approach gives analysts the ability to create well-defined candidate subtypes based on statistical properties. We demonstrate the utility of our approach in three case studies, where we show that we are able to reproduce findings from a published cancer subtype characterization.
Forschungs-