Exact Synthesis of Biomolecular Protocols for Multiple Sample Pathways on Digital Microfluidic Biochips
Sprache des Titels:
Englisch
Original Buchtitel:
International Conference on VLSI Design (VLSI Design)
Original Kurzfassung:
Digital-microfluidic biochips (DMFBs) allow laboratory
steps associated with genomic bioassays to be carried
out in an automated and highly efficient fashion. However,
to support complex (multi-sample) biomolecular protocols for
quantitative analysis, conventional design-automation methods
are ineffective, thereby motivating the need for more suitable
solutions. While first methods to address this problem have
recently been introduced, they neglect architectural details and
technology-related constraints, and use heuristics to oversimplify
the search for a design solution. These simplifications result in
designs that may either not be realizable on a DMFB or it is not
possible to evaluate how far they are from being optimal. In this
work, we propose an exact synthesis method that does not rely on
simplistic models and heuristics, but solves the underlying design
problem in an exact fashion. The proposed method allows for the
determination of exact and realistic results for the realization of
quantitative-analysis biomolecular protocols on DMFBs.
Forschungs-