A reduced-order model for red blood cell dynamics in blood flow
Sprache des Titels:
Proceedings of the 6th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2019
Understanding blood rheology plays an essential role in developing new bio-microfluidic systems.
Modelling the dynamic behavior of biological cells in blood flow such as red blood cell (RBC) has
been a challenge in the past decades due to their complex physics. Several computational methods
have been developed to model RBC dynamics but they mostly entail high computational costs. In
the present study, we propose a reduced-order model to overcome this limitation by representing
RBC as an arrangement of bonded spheres in interaction with the surrounding fluid. The model is
implemented in the framework of resolved CFD-DEM. A micro-channel full of suspended RBCs
in blood plasma corresponding to hematocrits of 0.15, 0.3 and 0.45 was simulated. The dynamic
behavior of RBCs such as deformation, tumbling and etc, as well as the formation of the cell free
layer near the channel wall and the velocity are investigated. Accordingly, the change in the apparent
viscosity of whole blood is analyzed showing a good agreement with previous literature.