Anna Mursch-Edlmayr, Dominika Podkowinski, Nikolaus Luft, Leopold Schmetterer, Michael Ring, Matthias Bolz,
"Effects of three intravitreal injections of aflibercept on the ocular circulation in eyes with age-related maculopathy."
, in British Journal of Ophthalmology, Vol. 104, Nummer 1, BMJ PUBLISHING GROUP, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND, WC1H 9JR, Seite(n) 53-57, 4-2019, ISSN: 1468-2079
Original Titel:
Effects of three intravitreal injections of aflibercept on the ocular circulation in eyes with age-related maculopathy.
Sprache des Titels:
Englisch
Original Kurzfassung:
Aims To investigate changes in ocular perfusion following three consecutive intravitreal injections with aflibercept for treatment of neovascular age-related macular degeneration (nAMD).
Methods The study included 20 eyes from 20 Caucasian patients with unilateral nAMD and 20 fellow eyes. All nAMD eyes were treated with standard intravitreal injection of aflibercept (IVA; 2 mg). Measurements of ocular perfusion at the optic nerve head (ONH) and the choroid were performed with laser speckle flowgraphy (LSFG). Measurements were conducted at baseline, 1?week after the first injection, at the time point of the second and third injection as well as 1 month after the third injection.
Results In treated eyes, mean blur rate (the main output parameter of LSFG) in the ONH microvasculature and in the choroid was significantly reduced 1 week after the first IVA treatment. The effect persisted throughout the entire follow-up period (p<0.001). No change in ocular perfusion was observed in fellow eyes.
Conclusions IVA for treatment of nAMD leads to a reduction in perfusion of the ONH and the choroid in the treated eye with no apparent effect on the fellow eye.
Sprache der Kurzfassung:
Englisch
Journal:
British Journal of Ophthalmology
Veröffentlicher:
BMJ PUBLISHING GROUP, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND, WC1H 9JR