PTPIP51 crosslinks the NF?B signaling and the MAPK pathway in SKBR3 cells
Sprache des Titels:
Breast cancer is the most common cancerous disease among women. Prognosis and therapy ofbreastcancerdependsontheexpressionofhormoneandsurfacereceptorssuchasHer2,whichpromote tumor growth and invasion via activation of downstream signaling pathways. NF?B signaling represents a downstream signaling pathway that can be activated by Her2. In this study, we demonstrated that inhibition of NF?B signaling with IKK-16 reduces cell viability in breast cancer cells with amplified Her2. Furthermore,weidentifiedPTPIP51asapotentialmediatorofcrosstalksbetweentheMAPKpathwayand NF?B signaling. This signaling pathway could therefore be a target for future drug development.