Gerold Fink, Medina Hamidovic, Robert Wille, Werner Haselmayr,
"Passive Droplet Control in Two-Dimensional Microfluidic Networks"
, in IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, 2020, ISSN: 2372-2061
Original Titel:
Passive Droplet Control in Two-Dimensional Microfluidic Networks
Sprache des Titels:
Englisch
Original Kurzfassung:
Microfluidic networks for droplet-based microfluidics have been recently introduced with the aim of realizing
flexible Lab-on-Chip devices. In this paper, we investigate, for
the first time, a two-dimensional network topology, in which
biological samples, embodied in so-called payload droplets, are
delivered to a specific destination. Two-dimensional networks
can be useful in many applications, such as the automation
of laboratory experiments on microwell plates. The path of the
payload droplet is determined by the network geometry and the
distance to so-called control droplets (i.e., passive droplet control).
In order to route single or multiple payload droplets to a specific
destination, we introduce droplet frames that include single or
multiple payload droplets and several control droplets for their
path control. We derive closed-form expressions for the droplet
distances within the frame to realize the desired droplet routing.
These expressions are solely based on the network geometry
and fluid properties. Computer simulations based on the analogy
between microfluidic networks and electrical circuits verified the
proposed routing scheme.
Sprache der Kurzfassung:
Englisch
Journal:
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
Forschungs-