Much of the increasing complexity of ICT systems is being driven by the more distributed and heterogeneous nature of these systems, with Cyber-Physical Systems (CPS) accounting for an increasing portion of Software Ecosystems. Blending best practices DevOps solutions with the development processes used in the CPS to deliver software more rapidly and result in a more secure manner are emerging and critical open challenges of both contemporary and future CPS development. The core part of required solutions needs more advanced test automation and deployment strategies, which work efficiently and in an adaptive manner in different CPS domains, while addressing different CPS technical requirements. However, research in the field is in early stage for what concerns DevOps automation for CPSs, and simply running test cases in DevOps pipelines is still limited. Now testing and deployment automation needs to rise to the next level by going beyond mere test execution of ?software systems?, for which Hardware-in-the-Loop (HIL) activities are not required as with CPS. Moreover, while software engineers, artificial intelligence (AI) engineers and data scientists are actively working on such issues, very few work have been done to address the most emerging challenges involving CPS, which requires the expertise of all these experts.