Synthesis of functionalized porphyrinoid compounds to increase and optimize antiproliferative effects in neuroendocrine tumors
Sprache des Vortragstitels:
Natural Anticaner Drugs
Sprache des Tagungstitel:
Cationic porphyrins represent an expanding class of
compounds, which have several applications in biology,
medicine and catalysis and have been studied from the
viewpoint of their role as DNA cleavers, G-Quadruplex
DNA stabilizers and downregulators of proto-oncogenes
(RET, c-Myc, Ras, ERK etc.). Recent studies about the
interaction of cationic porphyrins and their derivatives
with telomeric DNA have moved porphyrin compounds
into the spotlight of an alternative anticancer strategy.
The tumoristatic effects of novel completely water soluble symmetric and asymmetric non-metalated and metalated porphyrinoid compounds were evaluated on two cancer types: a) small intestinal neuroendocrine tumor cells (SI-NETs), and b) medullary thyroid carcinoma cells (MTCs). In addition, the intracellular mechanism was elucidated. The tumoristatic effects could be selectively altered on specified neuroendocrine tumors by specific chemical modification of the porphyrinoid compounds.