Synthesis of polymers and drugs for cancer (immuno) therapy
Sprache des Vortragstitels:
Englisch
Original Tagungtitel:
1st Austrian-Czech Metabolomics-Workshop
Sprache des Tagungstitel:
Englisch
Original Kurzfassung:
The chemical synthesis and biological activity of novel
functionalized imidazoquinoline derivatives (ImQ) to generate Toll-like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirmed in zebrafish larvae. After covalent ligation to fully biodegradable polyphosphazenes (ImQpolymer), the macromolecular prodrugs were designed to undergo intracellular pH-sensitive release of ImQs to induce inflammation through binding to endosomal TLR7/8 (danger signal). We showed ImQ dissociation from prodrugs at a pH 5 pointing towards endosomal prodrug degradability. ImQ-polymers strongly activated ovalbuminspecific T cells in murine splenocytes as shown by increased proliferation and expression of the IL-2 receptor (CD25) on CD8+ T cells accompanied by strong IFN-? release. ImQ prodrugs presented here are suggested to form the basis of novel nanovaccines, e.g. for intravenous or intratumoral cancer immunotherapeutic applications to trigger physiological antitumor immune responses.
Sprache der Kurzfassung:
Englisch
Vortragstyp:
Hauptvortrag / Eingeladener Vortrag auf einer Tagung
Vortragsdatum:
24.05.2018
Vortragsort:
Österreich
Details zum Vortragsort:
Within the framework of the cross-border project ATCZ-52 METABO-BL ?Infrastruktur für Metabolomik-Forschung und medizinische Chemie/ Infrastruktura pro metabolomický výzkum a léka?skou chemii?
Forschungs-